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Design, Synthesis, Characterization and Bioactivity Evaluation of New Symmetric Disulfonamides and Dicarbamates of 4,4'-Oxydianiline

[ Vol. 15 , Issue. 1 ]

Author(s):

Pulluru Hari Babu, Chamarthi Naga Raju, A. Narasimhulu Chetty, P. V. Chalapathi, P. Sreenivasa Murthy and M. Nagalakshmi Devamma   Pages 25 - 32 ( 8 )

Abstract:


Background: A series of new symmetric disulfonamide and dicarbamate derivatives of 4,4ˈ- oxydianiline were designed and synthesized in a simple method. These compounds were characterized by IR, 1H, 13C-NMR, mass spectral data and elemental analysis.

Method: The compounds were screened for their in vitro antibacterial and antifungal activities against various pathogenic organisms. Among the title compounds 10f, 10a and 10h showed promising antibacterial activity and 10g, 10d and 10a showed good antifungal activity.

Conclusion: The results also emphasized that the disulfonamide derivatives were better antibacterial agents than the corresponding dicarbamate derivatives.

Keywords:

4, 4'-oxydianiline, disulfonamides, false metabolite, dicarbamates, sulphorhodamine-B (SRB) assay method, antibacterial activity, antifungal activity.

Affiliation:

Department of Chemistry, P.V.K.N. Government College, Chittoor, Andhra Pradesh, Department of Chemistry, Faculty of Sciences, Sri Venkateswara University, Tirupati, India; P.O. Box: 517 502, Department of Chemistry, P.V.K.N. Government College, Chittoor, Andhra Pradesh, Department of Chemistry, S.V. Arts College (TTDs), Tirupati, Chittoor Dist, Andhra Pradesh, Department of Botany, Sri Venkateswara University, Tirupati, Chittoor Dist, Andhra Pradesh, Department of Botany, Sri Venkateswara University, Tirupati, Chittoor Dist, Andhra Pradesh

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