Lavjot Kaur, Rakesh Kumar, Deepak Kumar Rahi and Vivek Ranjan Sinha* Pages 95 - 104 ( 10 )
Background: Microemulsion is one of the promising sub-micron carriers for topical drug delivery as it offers advantages like high drug-loading capacity and good skin penetration. Microemulsion based gel of voriconazole (broad-spectrum antifungal agent) could be an effective strategy for treatment of topical fungal infections.
Objective: To develop microemulsion based hydrogel of voriconazole was for effective treatment of skin mycosis.
Methods: Optimized microemulsion batches were selected through pseudoternary phase diagram (using oleic acid, tween 80 and IPA as oil, surfactant and co-surfactant, respectively) followed by stability studies and characterization.
Results: The drug content and pH were found in the desired range. The droplet size of optimized formulations were found within the desired range (<200nm). The hydrogel prepared (from selected microemulsion batches) were found to have good spreadability and texture (adequate adherence). The in-vitro and ex-vivo studies exhibited effective VCZ flux from microemulsion based gel. The skin retention of the drug from F12-Me-Gel was significantly higher when compared with the microemulsion (F12-ME) as well as the conventional gel. Similarly, the diameter of the zone of inhibition (against Candida albicans) of F12-Me-Gel found to be higher than the microemulsion batch (F12-ME). Moreover, the skin irritation studies confirmed the benignity of the microemulsion based gel. Furthermore, the formulation was found to be stable at various temperatures (5 ± 3, 25 ± 2 and 40 ± 2 °C) as reported by the stability studies.
Conclusion: Voriconazole loaded microemulsion based gel could be used effectively for the treatment of topical fungal infections.
Microemulsion, hydrogel, voriconazole, pseudoternary phase diagram, Candida albicans, sub-micron carriers, cosurfactant.
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh -160 014, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh -160 014, Department of microbiology, Panjab University, Chandigarh -160 014, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh -160 014