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Design, Synthesis and Antimicrobial Activity of Some Triazine Chalcone Derivatives

[ Vol. 18 , Issue. 4 ]

Author(s):

Ravindra Sandipan Shinde*, Satish Ashruba Dake and Rajendra Pundalikrao Pawar   Pages 332 - 338 ( 7 )

Abstract:


Background: A series of Triazine Chalcone derivatives were synthesized by the condensation of 1-(4-((4,6-dimethoxy-1,3,5-triazin-2-yl)amino)phenyl)ethanone with substituted benzaldehyde in methanol solvent.

Methods: All the synthesized derivatives (3a-l) were screened for their anti-bacterial evaluation against Gram negative bacteria Escherichia coli (NCIM 2137) and Pseudomonas aeruginosa (NCIM 2036); Gram positive bacteria Staphylococcus aureus, Bacillus subtilis (NCIM 2250) and four fungal stains. Candida albicans (MTCC 227), Aspergillus niger (NCIM 545), Candida tropicalis (NCIM 3110) and Candida glabrata (NCIM 3236).

Results and Conclusion: Several target molecules throughout the series showed good antibacterial and antifungal activity against tested stains.

Keywords:

Antibacterial, antifungal, antimicrobial activity, Benzaldehyde, Chalcone, 4, 6-dimethoxy-N-phenyl-1, 3, 5-triazin-2- amine, triazine.

Affiliation:

Department of Chemistry, Dayanand Science College, Latur-413512, MS, Department of Basic Science and Humanities, Deogiri Institute of Engineering and Management Studies, Station Road, Aurangabad-431005, (MS), Department of Chemistry, Deogiri College, Aurangabad-431 005, MS

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