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Enoyl-Acyl Carrier Protein Reductase (INHA): A Remarkable Target to Exterminate Tuberculosis

Author(s):

Surabhi Jain*, Smriti Sharma, Dhrubo Jyoti Sen and Saurabh S Pandya   Pages 1 - 15 ( 15 )

Abstract:


Tuberculosis, epidemic that needs new molecules with high potency and minimum side effects. In same respect, this review emphases on important target enoyl-acyl carrier protein reductase or INHA crucial in completion of FAS II cycle. INHA retain its fame since inception of drug Isoniazid as inhibitors have long residence time hence good activity. One of the cause of failure of conventional drugs is resistance towards activating or target gene. Here, we propose direct inhibitors that doesn’t need prior activation by Kat G. Some of the categories are aryl amide, Piperazine, Thiadiazole, Benzamide etc. that are specifically active against INHA along with their Structure activity relationship. Many of them are efficient in micro molar concentration whereas Pyrazole carboxamide are active in nano molar concentration and derivative of 4-hydroxy pyridones was effective in vivo. Natural products are also in way to combat tuberculosis. Furthermore, from available proteins of wild and mutant strains new leads can be designed sucessfully by utilizing information of cocrystallized ligand.

Keywords:

Tuberculosis, Enoyl-acyl carrier protein reductase, direct inhibitors, FAS II cycle, pyridomycin, KAT G.Tuberculosis, Enoyl-acyl carrier protein reductase, direct inhibitors, FAS II cycle, pyridomycin, KAT G.

Affiliation:

Faculty of Pharmacy, B. Pharmacy College Rampura-kakanpur, (Gujarat Technological University), Panchmahals, Gujarat, Amity Institute of Pharmacy, Amity University, Sector-125, Noida-201313, School of Pharmacy, Techno India University, Sector-V, EM-4, Salt Lake Campus, Kolkata-700091, West Bengal, Faculty of Pharmacy, B. Pharmacy College Rampura-kakanpur, (Gujarat Technological University), Panchmahals, Gujarat



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